Introduction:
- Cancer is a type of genetic disease that is often caused by accumulated DNA mutation.
- A tumour itself is the major source of tumour DNA and dying tumour cells could release small pieces of their DNA into the bloodstream. These pieces are referred to circulating tumour DNA (ctDNA). Owing to its high specificity to tumour, ctDNA is regarded as an effective yet non-invasive cancer biomarker.
Application:
- Could detect 38 commonly seen tumours at once
- Could monitor the situation of tumour recurrence
Below are the 38 commonly seen tumours:
Bladder & Urinary Tract Cancer: Bladder urinary tract epithelium tumor (BUC)
Brain Cancer: Low grade glioma, Glioblastoma Multiforme (GBM)
Cholangiocarcinoma: Cholangiocarcinoma
CNS Cancer: Medulloblastoma and paraganglioma, Astrocytoma, Neuroblastoma
Colorectal Cancer: Carcinoma of colon, Rectal adenocarcinoma
Endocrine Cancer: Multiple endocrine neoplasia - Type 2A, Multiple endocrine neoplasia - Type 2B, Adrenal cortical tumor
Esophageal cancer: Esophageal cancer
Eye Cancer: Malignant melanoma of uvea, Retinoblastoma
Gastric Cancer:Gastric adenocarcinoma, Diffuse gastric cancer, Gastrointestinal stromal tumors
H&N Cancer: Head and neck squamous cell carcinoma
Leukemia: Acute myeloid leukemia (AML), Chronic lymphocytic leukemia
Liver Cancer: Hepatocellular carcinoma
Lung Cancer: Lung adenocarcinoma, Lung squamous cell carcinoma, Small cell lung cancer
Mesothelioma: Mesothelioma
Pancreas Cancer: Pancreatic adenocarcinoma
Renal Cancer: Kidney chromophobe cell carcinoma, Renal papillary cell tumor, Kidney clear cell carcinoma
Rhabdoid tumor: Rhabdoid tumor
Sarcoma: Sarcoma
Skin Cancer: Malignant melanoma of skin, Basal cell carcinoma (BCC)
Thymoma: Thymoma
Thyroid Cancer: Familial medullary thyroid carcinoma
Prostate Cancer: Prostate Cancer
Testicular Cancer: Testicular germ cell tumor
Specimen:
Reporting Time:
- Around 6 weeks working days
Report explanation by Genetic Counsellor via phone